Endocrine Abstracts

Introduction: Quality of life (QoL) and its related physical and psychological symptomatology is an important factor when we treat Graves’ disease.Objective: To analyze the QoL and physical and psychological symptomatology of patients with hypothyroidism after definitive treatment of Graves’ disease.Methods: We evaluated 16 patients with hypothyroidism that previously had Graves’ disease. These patients were submitte...

Objectives: Thyroid peroxidase (TPO) is a key enzyme in the synthesis of thyroid hormones and is a target for autoimmune responses in autoimmune thyroid disease. TPO autoantibody (TPOAb) binding epitopes have been mapped on the peroxidase domain (POD) and the complement control protein like domain (CCP). This study aimed to solve the molecular structures of TPO bound to TPO antibodies.Methods: An extracellular domain (ECD) of human TPO (amino acids; aa 1...

Background: The hypothalamic-pituitary-adrenal (HPA) axis can be suppressed by long-term exogenous glucocorticoids, resulting in tertiary adrenal insufficiency (AI). International expert consensus suggests that during weaning, prednisolone be converted to hydrocortisone to allow HPA axis reactivation(1). There is, however, little evidence to support this practice.Aim: To compare HPA axis recovery during treatment with prednisolone and immediat...

Introduction: The clinical and biochemical spectrum of pituitary acromegaly is wide and variable. There are pure somatotroph tumors(ST), immunohistochemically positive only for GH, and pluri-hormonal(PL), also positive for other hormones, and they appear to have different presentations and responses to treatment.Aims: To compare the clinical presentation, imaging characteristics and response to treatment of acromegalic patients according to the pituitary...

Introduction: Anomalies of glucose metabolism and insulin resistance are common in patients with hypothyroidism. Some studies suggests that euthyroid autoimmune thyroiditis (AIT) may also be associated with changes of glucose metabolism and insulin resistance. The role of thyroid hormones resistance in this context is still uncertain.Aim: To evaluate the relationship between thyroid hormones resistance, insulin resistance and lipid profile in euthyroid p...

Introduction: Oestrogens and androgens modulate the effects of growth hormone (GH). Sex differences have been described in acromegaly, with conflicting results in different populations. Additionally, data on sex differences in tumour histopathology are scarce.Aims: To analyse the influence of sex and menopause status in tumour characteristics and surgical outcomes in patients with acromegaly.Materials and methods: Retrospective coh...

Introduction: Prolactinoma is the most frequent secreting pituitary tumor. They are usually treated with dopamine agonists (DA) (bromocriptine and cabergoline), which are very effective in most cases. DA resistance consists of the impossibility of reaching normal prolactin levels and/or reduction of the adenoma by at least 50%.Case presentation: We present the case of a 57-year-old man affected by visual disturbances and hypopituitarism (2019). Pituitary...

Introduction: Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a malignant neuroendocrine tumor of the nasal fossa that arises from neurosensory receptor cells of the olfactory epithelium. It represents 3% of all nasal tumors. It presents a slow and progressive evolution that primarily affects the upper nasal mucosa and cribriform plate, with subsequent extension to the entire cavity and paranasal sinuses and can invade the orbit and cranial base.<p c...

Objective: To assess the prevalence of complications In a cohort of patients with type 2 diabetes mellitus (T2DM).Material and methods: Prospective cohort study. 465 patients with T2DM who were not followed-up at an endocrinology clinic were included. The follow-up was carried out during 26 weeks. The prevalence of complications was evaluated throughout the study. This study was approved by the Ethics and Clinical Research Committee of the University Hos...

Introduction: Most recent ATA thyroid nodule/DTC guidelines recommend thyroidectomy without prophylactic CND for small (T1 or T2), non-invasive, clinically node-negative PTC (cN0). However, some studies have suggested an association between the BRAFV600E mutation and the risk of nodal disease. Moreover, BRAF V600E mutation have recently showed significant association with recurrence in solitary intrathyroidal PTC between 2 and 4 cm (pT2) making suitable a more aggressive treat...